Kaemmerer, H.H.KaemmererBauer, U.U.BauerStein, J. L.J. L.SteinLemp, S.S.LempBartmus, D.D.BartmusHoffmann, A. L.A. L.HoffmannNiesert, S.S.NiesertOsmers, R.R.OsmersFratz, S.S.FratzRossa, S.S.RossaLange, Peter E.Peter E.LangeBeitzke, A.A.BeitzkeSchneider, KTMKTMSchneiderHess, J.J.Hess2018-11-072018-11-072003https://resolver.sub.uni-goettingen.de/purl?gro-2/46956Objectives Aim of this study was to assess the occurrence of pregnancy-related complications of mother and child during pregnancy, delivery and puerperium in women with CCD prospectively. Study Design, Population. This prospective multicenter study included 122 pregnancies in 106 women with CCD (72 with, 34 without previous cardiac surgery). Patient age was 17-44, median 26 years. Cardiac and non-cardiac complications, mode of delivery, abortion, and CCD of the newborn were assessed. Results Initially all women were in Functional Class I or II. Worsening during pregnancy occurred in 25.5% (n = 27), mainly during the second and third trimester. Significant problems due to bleeding, hypertension, rhythm disturbances, endocarditis, liver congestion, increasing cyanosis or death, occurred in 11.3%. Twelve per cent of deliveries were premature. Five women had therapeutic abortion, nine spontaneous abortions, nine preterm births, and one intrauterine death. Seventy-nine per cent (n = 85) delivered spontaneously; 21.3% (n = 23) had caesarean section. Of the 111 live born children, 5.4% (n=6) had a CCD. Conclusions Most women with CCD and a good functional class before pregnancy tolerate pregnancy without major problems. However, pregnancy may induce serious cardiac and obstetric complications. The specific risks require an individualized multidisciplinary patient-management by experienced physicians.review10.1007/s00392-003-0880-012545297000180935900002