Jakob, JensJensJakobSmith, Henry G.Henry G.SmithWilkinson, Michelle J.Michelle J.WilkinsonPencavel, TimTimPencavelMiah, Aisha B.Aisha B.MiahThomas, Joseph M.Joseph M.ThomasTunn, Per-UlfPer-UlfTunnPilz, Lothar R.Lothar R.PilzStrauss, Dirk C.Dirk C.StraussHohenberger, PeterPeterHohenbergerHayes, Andrew J.Andrew J.Hayes2020-11-232020-11-232018https://resolver.sub.uni-goettingen.de/purl?gro-2/68991Induction chemotherapy by isolated limb perfusion (ILP) with melphalan and tumour necrosis factor-α is an effective strategy to facilitate limb-conserving surgery in locally advanced extremity sarcoma. In a comparison of cohorts matched for grade, size and surgical resectability, we compared the outcome of patients undergoing induction ILP prior to limb-conserving surgery and selective post-operative radiotherapy with patients undergoing limb-conserving surgery and routine post-operative radiotherapy.enRegional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohortsjournal_article10.1186/s13569-018-0098-629988594