Krasnianski, AnnaAnnaKrasnianskivon Ahsen, NicolasNicolasvon AhsenHeinemann, UtaUtaHeinemannMeissner, BettinaBettinaMeissnerSchulz-Schaeffer, Walter J.Walter J.Schulz-SchaefferKretzschmar, Hans A.Hans A.KretzschmarArmstrong, Victor WilliamVictor WilliamArmstrongZerr, IngaIngaZerr2018-11-072018-11-072009https://resolver.sub.uni-goettingen.de/purl?gro-2/17097Objective: To analyze whether a positive family history of dementia (PFHD) is more common in sporadic CJD (sCJD) than in healthy/population controls and to study associated risk factors. Patients/methods: Six hundred and eighty-five sCJD patients and 659 sex/age-matched controls were included. A PFHD in parents/grandparents/siblings was evaluated. The PRNP M129V polymorphism and ApoE genotype in sCJD with/without PFHD were determined by PCR. Results: PFHD was found in 12.1% of sCJD patients and 5.6% of controls (p < 0.001). No significant difference in M129V polymorphism was found between sCJD with and without PFHD. Thirty-six percent of sCJD patients with PFHD, 26% without PFHD and 19% of healthy controls had at least one ApoE4 allele. Compared to controls, ApoE4 allele frequency (p = 0.005) and proportion of ApoE4 allele carriers (p = 0.019) were significantly higher in sCJD with PFHD. Interpretation: A higher frequency of the ApoE4 allele in sCJD with a PFHD could be indicative of an additional risk factor in CJD. (C) 2007 Elsevier Inc. All rights reserved.journal_article10.1016/j.neurobiolaging.2007.07.01417822808000264579500017