Winker, M.M.WinkerStössel, S.S.StösselNeu, M. A.M. A.NeuLehmann, N.N.LehmannEl Malki, KKEl MalkiParet, CCParetJoisten, NiklasNiklasJoistenBloch, W.W.BlochZimmer, P.P.ZimmerFaber, J.J.Faber2024-07-092024-07-092021https://resolver.sub.uni-goettingen.de/purl?gro-2/144172While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025.enGRO Licensejournal_article10.1007/s00520-021-06719-334860287http://europepmc.org/abstract/med/34860287PMC8857093