Facoetti, DiegoDiegoFacoettiAbbiati, GiorgioGiorgioAbbiatid’Avolio, LauraLaurad’AvolioAckermann, LutzLutzAckermannRossi, ElisabettaElisabettaRossi2018-11-072018-11-072009https://resolver.sub.uni-goettingen.de/purl?gro-2/56642Easily accessible N-ethoxycarbonyl-2-alkynylindoles undergo, in the presence of primary aryl amines and under TiCl(4)/t-BuNH(2) catalysis, domino hydroamination-annulation reactions giving rise to pyrimido[1,6-a]indolones in good to excellent yields. The reaction involves an initial highly regio- and chemoselective hydroamination reaction. The obtained compounds show interesting fluorescence properties and could represent a new class of useful markers for bioanalytical purpose.journal_article10.1055/s-0029-1217807000271022900010