Stahl, A.A.StahlPaschek, L.L.PaschekMartin, G.G.MartinGross, N. J.N. J.GrossFeltgen, N.N.FeltgenHansen, L. L.L. L.HansenAgostini, H. T.H. T.Agostini2019-07-092019-07-092008https://resolver.sub.uni-goettingen.de/purl?gro-2/60313Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments.enGoescholarhttps://goescholar.uni-goettingen.de/license610Angiogenesis InhibitorsApoptosisCells, CulturedChoroidal NeovascularizationCoculture TechniquesHumansPigment Epithelium of EyeSirolimusVascular Endothelial Growth Factor Ajournal_article10.1016/j.febslet.2008.08.00518703055https://resolver.sub.uni-goettingen.de/purl?gs-1/6261