Leygraf, A.A.LeygrafHohoff, ChristaChristaHohoffFreitag, Christine M.Christine M.FreitagWillis-Owen, S. A.S. A.Willis-OwenKrakowitzky, PetraPetraKrakowitzkyFritze, JuergenJuergenFritzeFranke, Petra E.Petra E.FrankeBandelow, BorwinBorwinBandelowFimmers, RolfRolfFimmersFlint, J.J.FlintDeckert, J.J.Deckert2018-11-072018-11-072006https://resolver.sub.uni-goettingen.de/purl?gro-2/22701Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mice. Therefore we investigated four non-coding single nucleotide polymorphisms in a sample of 173 patients with panic disorder and 173 matched controls of German descent. At the genotype level all four SNPs were associated with panic disorder (p=0.02-0.05). At the haplotype level the strongest association was observed for a haplotype containing SNP3 and SNP 4 (subgroup men and men with agoraphobia: p=0.01 and 0.03). This points towards a functional polymorphism at the 3' end of the gene. Our results support the hypothesis that variations of the Rgs2 gene play a role also for the development of anxiety in humans.journal_article10.1007/s00702-006-0484-816736243000243526000013