von Moers, A.A.von MoersBrockmann, KnutKnutBrockmannWang, D.D.WangKorenke, C. G.C. G.KorenkeHuppke, PeterPeterHuppkeDe Vivo, D. C.D. C.De VivoHanefeld, FolkerFolkerHanefeld2018-11-072018-11-072002https://resolver.sub.uni-goettingen.de/purl?gro-2/40304Purpose: Glut-1 deficiency syndrome (Glut-1 DS) is caused by the deficiency of the major glucose transporter in cerebral microvessels. Methods: We performed pre- and postprandial EEG recordings in two unrelated children with Glut-1 DS with developmental delay and seizures predominantly in the morning before breakfast. Results: Extensive epileptiform discharges observed in the fasting state were improved markedly by food intake, as documented in EEG recordings 1 and 2 h after a meal. The ratio of cerebrospinal fluid glucose to blood glucose was decreased in both children. Glut-1 deficiency was confirmed by biochemical and molecular genetic investigations. Conclusions: Pre- and postprandial EEG recordings offer a simple screening test for Glut-1 DS.journal_article10.1046/j.1528-1157.2002.50401.x12181017000177383900024