Brackmann, F.F.BrackmannYufit, Dmitry S.Dmitry S.YufitHoward, JAKJAKHowardEs-Sayed, M.M.Es-Sayedde Meijere, ArminArminde Meijere2018-11-072018-11-072005https://resolver.sub.uni-goettingen.de/purl?gro-2/17169tert-Butyl N-[1-(hydroxymethyl)cyclopropyl]carbamate (8) was converted into spirocyclopropanated analogues 14-CP and 14-CT of the insecticide Thiacloprid (2) in six simple steps with overall yields of 24% each, along with their regioisomers 13-CP and 13-CT in overall yields of 17 and 15%, respectively. The spirocyclopropanated analogues 27-CP and 27-CT of the insecticide Imidacloprid (1) were prepared from 8 in five steps in an overall yield of 10% each, along with their regioisomers 20-CP and 20-CT in an overall yield of 8 and 7%, respectively. The key step in all preparations was a cocyclization of an appropiately protected (1-aminocyclopropyl)methyl derivative with S,S-dimethyl cyanodithioirninocarbonate (11) or nitroguanidine (22). The structures of several final products and by-products were verified by X-ray crystal structure analyses.journal_article10.1002/ejoc.200400599000226795300015