Mansur, AshhamAshhamMansurKlee, YvonneYvonneKleePopov, Aron-FrederikAron-FrederikPopovErlenwein, JoachimJoachimErlenweinGhadimi, Michael B.Michael B.GhadimiBeißbarth, TimTimBeißbarthBauer, MartinMartinBauerHinz, José MariaJosé MariaHinz2018-11-072018-11-072015https://resolver.sub.uni-goettingen.de/purl?gro-2/38567Objective: To investigate whether common infection foci (pulmonary, intra-abdominal and primary bacteraemia) are associated with variations in mortality risk in patients with sepsis. Design: Prospective, observational cohort study. Setting: Three surgical intensive care units (ICUs) at a university medical centre. Participants: A total of 327 adult Caucasian patients with sepsis originating from pulmonary, intra-abdominal and primary bacteraemia participated in this study. Primary and secondary outcome measures: The patients were followed for 90 days and mortality risk was recorded as the primary outcome variable. To monitor organ failure, sepsis-related organ failure assessment (Sequential Organ Failure Assessment, SOFA) scores were evaluated at the onset of sepsis and throughout the observational period as secondary outcome variables. Results: A total of 327 critically ill patients with sepsis were enrolled in this study. Kaplan-Meier survival analysis showed that the 90-day mortality risk was significantly higher among patients with primary bacteraemia than among those with pulmonary and intra-abdominal foci (58%, 35% and 32%, respectively; p=0.0208). To exclude the effects of several baseline variables, we performed multivariate Cox regression analysis. Primary bacteraemia remained a significant covariate for mortality in the multivariate analysis (HR 2.10; 95% CI 1.14 to 3.86; p=0.0166). During their stay in the ICU, the patients with primary bacteraemia presented significantly higher SOFA scores than those of the patients with pulmonary and intra-abdominal infection foci (8.5 +/- 4.7, 7.3 +/- 3.4 and 5.8 +/- 3.5, respectively). Patients with primary bacteraemia presented higher SOFA-renal score compared with the patients with other infection foci (1.6 +/- 1.4, 0.8 +/- 1.1 and 0.7 +/- 1.0, respectively); the patients with primary bacteraemia required significantly more renal replacement therapy than the patients in the other groups (29%, 11% and 12%, respectively). Conclusions: These results indicate that patients with sepsis with primary bacteraemia present a higher mortality risk compared with patients with sepsis of pulmonary or intra-abdominal origins. These results should be assessed in patients with sepsis in larger, independent cohorts.CC BY-NC 4.0https://creativecommons.org/licenses/by-nc/4.0journal_article10.1136/bmjopen-2014-00661625564146000348171800032https://resolver.sub.uni-goettingen.de/purl?gs-1/11567