Westermann, FrankFrankWestermannMuth, DanielDanielMuthBenner, AxelAxelBennerBauer, TobiasTobiasBauerHenrich, Kai-OliverKai-OliverHenrichOberthuer, AndréAndréOberthuerBrors, BenediktBenediktBrorsBeißbarth, TimTimBeißbarthVandesompele, JoJoVandesompelePattyn, FilipFilipPattynHero, BarbaraBarbaraHeroKönig, RainerRainerKönigFischer, MatthiasMatthiasFischerSchwab, ManfredManfredSchwab2020-04-022020-04-022008-10-13https://resolver.sub.uni-goettingen.de/purl?gro-2/63493Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and protein levels are paradoxically associated with a more favorable clinical phenotype, including disseminated tumors that subsequently regress spontaneously (stage 4s-non-amplified). In this study, we asked whether distinct transcriptional MYCN or c-MYC activities are associated with specific neuroblastoma phenotypes.enjournal_article10.1186/gb-2008-9-10-r15018851746