Cukierman, Daphne SchneiderDaphne SchneiderCukiermanPinheiro, Ana BeatrizAna BeatrizPinheiroCastineiras-Filho, Sergio L. P.Sergio L. P.Castineiras-Filhoda Silva, Anastacia Sa P.Anastacia Sa P.da SilvaMiotto, Marco C.Marco C.MiottoDe Falco, AnnaAnnaDe FalcoRibeiro, Thales de P.Thales de P.RibeiroMaisonette, SilviaSilviaMaisonetteda Cunha, Alessandra L. M. C.Alessandra L. M. C.da CunhaHauser-Davis, Rachel A.Rachel A.Hauser-DavisLandeira-Fernandez, J.J.Landeira-FernandezAucelio, Ricardo Q.Ricardo Q.AucelioOuteiro, Tiago FlemingTiago FlemingOuteiroPereira, Marcos D.Marcos D.PereiraFernandez, Claudio O.Claudio O.FernandezRey, Nicolas A.Nicolas A.Rey2018-11-072018-11-072017https://resolver.sub.uni-goettingen.de/purl?gro-2/42717Alzheimer's and Parkinson's diseases share similar amyloidogenic mechanisms, in which metal ions might play an important role. In this last neuropathy, misfolding and aggregation of alpha-synuclein (alpha-Syn) are crucial pathological events. A moderate metal-binding compound, namely, 8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone (INHHQ), which was previously reported as a potential 'Metal-Protein Attenuating Compound' for Alzheimer's treatment, is well-tolerated by healthy Wistar rats and does not alter their major organ weights, as well as the tissues' reduced glutathione and biometal levels, at a concentration of 200 mg kg(-1). INHHQ definitively crosses the blood-brain barrier and can be detected in the brain of rats so late as 24 h after intraperitoneal administration. After 48 h, brain clearance is complete. INHHQ is able to disrupt, in vitro, anomalous copper-alpha-Syn interactions, through a mechanism probably involving metal ions sequestering. This compound is non-toxic to H4 (human neuroglioma) cells and partially inhibits intracellular alpha-Syn oligomerization. INHHQ thus, shows definite potential as a therapeutic agent against Parkinson's as well. (C) 2017 Elsevier Inc. All rights reserved.journal_article10.1016/j.jinorgbio.2017.02.02028249224000398881000017