Xiong, FengFengXiongLi, BoBoLiYang, ChenruiChenruiYangZou, LiangLiangZouMa, WenboWenboMaGu, LinghuiLinghuiGuMei, RuhuaiRuhuaiMeiAckermann, LutzLutzAckermann2021-08-122021-08-122021https://resolver.sub.uni-goettingen.de/purl?gro-2/88620The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N -2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.The efficient copper-mediated oxidative C–H alkynylation of benzhydrazides was accomplished with terminal alkynes. Thus, a heteroaromatic removable N -2-pyridylhydrazide allowed for domino C–H/N–H functionalization. The approach featured remarkable functional group compatibility and ample substrate scope. Thereby, highly functionalized aromatic and heteroaromatic isoindolin-1-ones were accessed with high efficacy with rate-limiting C–H cleavage.enjournal_article10.3762/bjoc.17.113