Cobalt(III)-Catalyzed C-H Alkynylation with Bromoalkynes under Mild Conditions

Sauermann, NicolasNicolasSauermannGonzalez, Maria J.Maria J.GonzalezAckermann, LutzLutzAckermann2018-11-072018-11-072015https://resolver.sub.uni-goettingen.de/purl?gro-2/35427Expedient cobalt-catalyzed C-H alkynylation was achieved under exceedingly mild reaction conditions. Thus, chelation-assisted direct alkynylations of heteroarenes occurred with 1-bromoalkynes and ample substrate scope. The optimized catalytic system allowed for step-economical C-H functionalizations with a mild base K2CO3 at reaction temperatures as low as 25 degrees C.Cobalt(III)-Catalyzed C-H Alkynylation with Bromoalkynes under Mild Conditionsjournal_article10.1021/acs.orglett.5b0267826492592000364434900043