Fasching, K.K.FaschingPanzer, S.S.PanzerHaas, Oskar A.Oskar A.HaasBorkhardt, ArndtArndtBorkhardtMarschalek, R.R.MarschalekGriesinger, FrankFrankGriesingerPanzer-Grumayer, E. R.E. R.Panzer-Grumayer2018-11-072018-11-072001https://resolver.sub.uni-goettingen.de/purl?gro-2/17663Childhood acute lymphoblastic leukemia (ALL) Is frequently initiated in utero at a time of developmentally regulated insertion of N regions into the DJ(H) rearrangements of immunoglobulin heavy-chain (Ig(H)) genes. Here it is shown that N regions are present In the clonotypic DJ(H) rearrangements In 11 of 12 infant ALLs with t(4;11). These data are compared with the 122 previously published DJ(H) sequences and were found to have a pattern similar to that of ALL in children older than 3 years at diagnosis but were unlike that in children younger than 3 years who predominantly lack N regions. These findings, therefore, indicate that t(4;11)-positive infant ALL is initiated later in fetal development than most B-cell precursor ALL from children younger than 3 years and that they have a shorter latency period already in utero. (C) 2001 by The American Society of Hematology.journal_article10.1182/blood.V98.7.227211568017000171302800043