Edelmann, FrankFrankEdelmannStahrenberg, RaoulRaoulStahrenbergPolzin, FriederikeFriederikePolzinKockskaemper, AnkeAnkeKockskaemperDuengen, Hans-DirkHans-DirkDuengenDuvinage, AndreAndreDuvinageBinder, LutzLutzBinderKunde, JanJanKundeScherer, MartinMartinSchererGelbrich, GötzGötzGelbrichHasenfuß, GerdGerdHasenfußPieske, BurkertBurkertPieskeWachter, RolfRolfWachterHerrmann-Lingen, ChristophChristophHerrmann-Lingen2017-09-072017-09-072011https://resolver.sub.uni-goettingen.de/purl?gro-2/188Background Quality of life (QoL) is impaired in diastolic heart failure. Little is known about QoL in diastolic dysfunction (DD) without heart failure. Methods In the DIAST-CHF observational study, outpatients with risk factors for or a history of heart failure were included. In a cross-sectional analysis, we classified patients with preserved systolic function as having normal diastolic function (N, n = 264) or DD without (DD-, n = 957) or with (DD+, n = 321) elevated filling pressures according to echocardiography. Quality of life was evaluated by the Short Form 36 (SF-36) questionnaire. Results Short Form 36 physical function (SF-36-PF) was worse in DD+ (mean +/- SD 67.2 +/- 25.6) than in DD- (76.2 +/- 22.7, P < .05) than in N (mean +/- SD 81.1 +/- 23.5, P < .01). Other physical dimensions and the physical component score were also lower in DD, whereas the mental component score did not differ. The SF-36-PF correlated weakly with echocardiographic indicators of diastolic function. In multivariate linear regression controlling for age, sex, body mass index, depressiveness as assessed by Patient Health Questionnaire 9, N-terminal probrain-type natriuretic peptide, and midregional proadrenomedullin (MR-proADM), individual echocardiographic parameters or grade of DD was not independently associated with SF-36-PF, whereas the presence of DD+ was. Both N-terminal probrain-type natriuretic peptide and MR-proADM were independently associated with SF-36-PF, with MR-proADM showing the stronger association. Conclusions Physical dimensions of QoL are reduced in DD. Impaired SF-36-PF is only weakly associated with DD per se but rather seems to be contingent on the presence of elevated filling pressures. Biomarkers are more strongly and independently associated with SF-36-PF and may be more adequate surrogate markers of QoL in DD than echocardiographic measurements. (Am Heart J 2011; 161: 797-804.)journal_article10.1016/j.ahj.2011.01.003214739810002891905000253142750