Ikegami, TakahisaTakahisaIkegamiVerdier, LaurentLaurentVerdierSakhaii, PeymanPeymanSakhaiiGrimme, SusanneSusanneGrimmePescatore, BarbaraBarbaraPescatoreSaxena, KrishnaKrishnaSaxenaFiebig, Klaus M.Klaus M.FiebigGriesinger, ChristianChristianGriesinger2017-09-072017-09-072004https://resolver.sub.uni-goettingen.de/purl?gro-2/1547A molecule with an anisotropic magnetic susceptibility is spontaneously aligned in a static magnetic field. Alignment of such a molecule yields residual dipolar couplings and pseudocontact shifts. Lanthanide ions have recently been successfully used to provide an anisotropic magnetic susceptibility in target molecules either by replacing a calcium ion with a lanthanide ion in calcium-binding proteins or by attaching an EDTA derivative to a cysteine residue via a disulfide bond. Here we describe a novel enantiomerically pure EDTA derived tag that aligns stronger due to its shorter linker and does not suffer from stereochemical diversity upon lanthanide complexation. We observed residual N-15, H-1-dipolar couplings of up to 8 Hz at 800 MHz induced by a single alignment tensor from this tag.enjournal_article10.1023/B:JNMR.0000032611.72827.de152134320002222112000113143974