Leibeling, MarkusMarkusLeibelingKoester, Dennis C.Dennis C.KoesterPawliczek, MartinMartinPawliczekSchild, Svenia C.Svenia C.SchildWerz, Daniel B.Daniel B.Werz2018-11-072018-11-072010https://resolver.sub.uni-goettingen.de/purl?gro-2/20486Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, followed by two carbopalladation steps and completed by a cyclization to annelate the benzene moiety. The versatility of this route has been demonstrated by a small library of highly substituted chromans and isochromans.journal_article10.1038/NCHEMBIO.302000274565100010