Salaverria, ItziarItziarSalaverriaMartin-Guerrero, IdoiaIdoiaMartin-GuerreroBurkhardt, BirgitBirgitBurkhardtKreuz, MarkusMarkusKreuzZenz, ThorstenThorstenZenzOschlies, IlskeIlskeOschliesArnold, NorbertNorbertArnoldBaudis, MichaelMichaelBaudisBens, SusanneSusanneBensGarcia-Orad, AfricaAfricaGarcia-OradLisfeld, JasminJasminLisfeldSchwaenen, CarstenCarstenSchwaenenSzczepanowski, MonikaMonikaSzczepanowskiWessendorf, SwenSwenWessendorfPfreundschuh, MichaelMichaelPfreundschuhTruemper, Lorenz H.Lorenz H.TruemperKlapper, WolframWolframKlapperSiebert, ReinerReinerSiebert2018-11-072018-11-072013https://resolver.sub.uni-goettingen.de/purl?gro-2/30900Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas. (c) 2012 Wiley Periodicals, Inc.journal_article10.1002/gcc.2201423073988000312544700004