Richter, SandySandyRichterHelm, ConradConradHelmMeunier, Frederic A.Frederic A.MeunierHering, LarsLarsHeringCampbell, Lahcen I.Lahcen I.CampbellDrukewitz, Stephan H.Stephan H.DrukewitzUndheim, Eivind A. B.Eivind A. B.UndheimJenner, Ronald A.Ronald A.JennerSchiavo, GiampietroGiampietroSchiavoBleidorn, ChristophChristophBleidorn2023-03-212023-03-212017-03-04https://resolver.sub.uni-goettingen.de/purl?gro-2/123017We present the first molecular characterization of glycerotoxin (GLTx), a potent neurotoxin found in the venom of the bloodworm Glycera tridactyla (Glyceridae, Annelida). Within the animal kingdom, GLTx shows a unique mode of action as it can specifically up-regulate the activity of Cav2.2 channels (N-type) in a reversible manner. The lack of sequence information has so far hampered a detailed understanding of its mode of action.enjournal_article10.1186/s12862-017-0904-428259138