Brodin, LennartLennartBrodinMilovanovic, DragomirDragomirMilovanovicRizzoli, Silvio O.Silvio O.RizzoliShupliakov, OlegOlegShupliakov2022-07-012022-07-012022https://resolver.sub.uni-goettingen.de/purl?gro-2/112184The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.https://creativecommons.org/licenses/by/4.0/journal_article10.3389/fmolb.2022.891508