Tsuneto, MotokazuMotokazuTsunetoKajikhina, EkaterinaEkaterinaKajikhinaSeiler, KatharinaKatharinaSeilerReimer, AndreasAndreasReimerTornack, JuliaJuliaTornackBouquet, CorinneCorinneBouquetSimmons, SzandorSzandorSimmonsKnoll, MarkoMarkoKnollWolf, IngridIngridWolfTokoyoda, KojiKojiTokoyodaHauser, AnjaAnjaHauserHara, TakahiroTakahiroHaraTani-ichi, ShizueShizueTani-ichiIkuta, KoichiKoichiIkutaGruen, Joachim R.Joachim R.GruenGruetzkau, AndreasAndreasGruetzkauEngels, NiklasNiklasEngelsWienands, JuergenJuergenWienandsYanagisawa, YukiYukiYanagisawaOhnishi, KazuoKazuoOhnishiMelchers, FritzFritzMelchers2018-11-072018-11-072014https://resolver.sub.uni-goettingen.de/purl?gro-2/34954B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology. (C) 2013 Elsevier B.V. All rights reserved.review10.1016/j.imlet.2013.11.01124284375000330502000008