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Regioselective synthesis of medium-sized bicyclic butenolides by Lewis acid catalyzed cyclization of cyclic 1,3-bis(trimethylsilyloxy)-1,3-butadienes with oxalyl chloride

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2000

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Amer Chemical Soc

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[GRAPHICS] A new strategy for the synthesis of medium-sized bicyclic gamma-alkylidenebutenolides is reported which involves Me3SiOTf-catalyzed cyclization of cyclic 1,3-bis(trimethylsilyloxy)-1,3-butadienes with oxalyl chloride.

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