The molecular arrangement of membrane-bound annexin A2-S100A10 tetramer as revealed by scanning force microscopy

Abstract

The first step in membrane aggregation mediated by the annexin A2-S100A10 heterotetrameric complex (annexin A2t) has been unraveled by in situ scanning force microscopy. It has been shown unambiguously that annexin A2t binds to solid-supported lipid bilayers simultaneously with both annexin A2 subunits.