Publication:
Influence of TGF-β1 on tumor transition in oral cancer cell and BMSC co-cultures

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dc.bibliographiccitation.firstpage731
dc.bibliographiccitation.issue5
dc.bibliographiccitation.journalJournal of Cranio-Maxillofacial Surgery
dc.bibliographiccitation.lastpage740
dc.bibliographiccitation.volume45
dc.contributor.authorBöhrnsen, Florian
dc.contributor.authorGodek, F.
dc.contributor.authorKiesel, J.
dc.contributor.authorKramer, Franz-Josef
dc.contributor.authorBrockmeyer, Phillipp
dc.contributor.authorSchliephake, Henning
dc.date.accessioned2018-06-25T07:36:02Z
dc.date.available2018-06-25T07:36:02Z
dc.date.issued2017-05
dc.description.abstractTGF-β1 signaling modulates epithelial mesenchymal transitions (EMT) of head and neck squamous cell carcinoma (HNSCC). Bone marrow mesenchymal stromal cells (BMSC) are able to exert a regulating influence on the expression of markers of EMT in HNSCC cells. It was thus the aim of this study to test the hypothesis that TGF-β1 modulates the interactions of tumor transition between BMSCs and HNSCC, affecting the expression of E-cadherin, Vimentin, Snail, Twist, MMP14 and beta-catenin. Furthermore, we analyzed alterations in the AKT-signaling of tumor and stroma cells.
dc.fs.pkfprnr43706
dc.identifier.doi10.1016/j.jcms.2017.02.009
dc.identifier.fs626954
dc.identifier.pmid28318921
dc.identifier.urihttps://resolver.sub.uni-goettingen.de/purl?gro-2/15132
dc.language.isoen
dc.notes.statusfinal
dc.relation.eissn1878-4119
dc.titleInfluence of TGF-β1 on tumor transition in oral cancer cell and BMSC co-cultures
dc.typejournal_article
dc.type.internalPublicationunknown
dspace.entity.typePublication

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