New biologically active rubiginones from Streptomyces sp.

Abstract

Four new polyketides, named rubiginone D-2 (2), 4-O-acetyl-rubiginone D-2 (3), rubiginone H (6) and rubiginone I (7) were isolated from the cultures of Streptomyces sp. (strain Go N1/5). Their structures were established by a detailed spectroscopic analysis. The absolute configuration of 3 was determined by derivatization with chiral acids (Helmchen's method). The rubiginones inhibit the growth of some Gram-positive bacteria and are cytostatically active against different tumor cell lines.