Determination of the Relative Configuration of -Amino Acid Esters Based on Residual Dipolar Couplings

Abstract

Configurational and conformational characterization of two synthetic -amino acid esters comprising an indan motif was achieved by residual dipolar couplings. We further observed that the stability of Q factors upon addition of structural noise substantially facilitates the selection of the correct structure. The two analyzed compounds differ by a single methyl group, which leads to a remarkable conformational change.