Browsing by Author "Saure, Daniel"

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    Cardiac Rehabilitation in German Speaking Countries of Europe—Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH—Part 2
    (MDPI, 2021-07-12)
    Schwaab, Bernhard
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    Bjarnason-Wehrens, Birna
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    Meng, Karin
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    Albus, Christian
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    Salzwedel, Annett
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    Schmid, Jean-Paul
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    Benzer, Werner
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    Metz, Matthes
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    Jensen, Katrin
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    Rauch, Bernhard
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    Bönner, Gerd
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    Brzoska, Patrick
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    Buhr-Schinner, Heike
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    Charrier, Albrecht
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    Cordes, Carsten
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    Dörr, Gesine
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    Eichler, Sarah
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    Exner, Anne-Kathrin
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    Fromm, Bernd
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    Gielen, Stephan
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    Glatz, Johannes
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    Gohlke, Helmut
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    Grilli, Maurizio
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    Gysan, Detlef
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    Härtel, Ursula
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    Hahmann, Harry
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    Herrmann-Lingen, Christoph  
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    Karger, Gabriele
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    Karoff, Marthin
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    Kiwus, Ulrich
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    Knoglinger, Ernst
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    Krusch, Christian-Wolfgang
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    Langheim, Eike
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    Mann, Johannes
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    Max, Regina
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    Metzendorf, Maria-Inti
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    Nebel, Roland
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    Niebauer, Josef
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    Predel, Hans-Georg
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    Preßler, Axel
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    Razum, Oliver
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    Reiss, Nils
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    Saure, Daniel
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    von Schacky, Clemens
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    Schütt, Morten
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    Schultz, Konrad
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    Skoda, Eva-Maria
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    Steube, Diethard
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    Streibelt, Marco
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    Stüttgen, Martin
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    Stüttgen, Michaela
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    Teufel, Martin
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    Tschanz, Hansueli
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    Völler, Heinz
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    Vogel, Heiner
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    Westphal, Ronja
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    Schwaab, Bernhard; Curschmann Klinik, D-23669 Timmendorfer Strand, Germany, prof.schwaab@drguth.de Medizinische Fakultät, Universität zu Lübeck, D-23562 Lübeck, Germany, prof.schwaab@drguth.de
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    Bjarnason-Wehrens, Birna; Institute for Cardiology and Sports Medicine, Department of Preventive and Rehabilitative Sport- and Exercise Medicine, German Sportuniversity Cologne, D-50933 Köln, Germany, Bjarnason@dshs-koeln.de
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    Meng, Karin; Institute for Clinical Epidemiology and Biometry (ICE-B), University of Würzburg, D-97080 Würzburg, Germany, k.meng@uni-wuerzburg.de
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    Albus, Christian; Department of Psychosomatics and Psychotherapy, Faculty of Medicine, University Hospital, D-50937 Köln, Germany, Christian.albus@uk-koeln.de
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    Salzwedel, Annett; Department of Rehabilitation Medicine, Faculty of Health Sciences Brandenburg, University of Potsdam, D-14469 Potsdam, Germany, annett.salzwedel@fgw-brandenburg.de
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    Schmid, Jean-Paul; Klinik Barmelweid AG, CH-5017 Barmelweid, Switzerland, Jean-Paul.Schmid@barmelweid.ch
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    Benzer, Werner; Reha-Klinik Montafon, A-6780 Schruns, Austria, wbenzer@cable.vol.at
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    Metz, Matthes; Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, D-69120 Heidelberg, Germany, matthes.metz@gmail.com
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    Jensen, Katrin; Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, D-69120 Heidelberg, Germany, Meinhard.kieser@imbi.uni-heidelberg.de
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    Rauch, Bernhard; Institut für Herzinfarktforschung Ludwigshafen, IHF, D-67063 Ludwigshafen am Rhein, Germany, Rauch.B@t-online.de Zentrum für ambulante Rehabilitation, ZAR Trier GmbH, D-54292 Trier, Germany, Rauch.B@t-online.de
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    Bönner, Gerd; Medizinische Fakultät, Albert-Ludwigs-Universität zu Freiburg, D-79104 Freiburg, Germany, boenner.mail@t-online.de
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    Brzoska, Patrick; Fakultät für Gesundheit, Universität Witten/Herdecke, Lehrstuhl für Versorgungsforschung, D-58448 Witten, Germany, patrick.brzoska@uni-wh.de
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    Buhr-Schinner, Heike; Ostseeklinik Schönberg-Holm, D-24217 Schönberg-Holm, Germany, hbuhr-schinner@t-online.de
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    Charrier, Albrecht; Private Practice, D-01328 Dresden, Germany, albrecht.charrier@t-online.de
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    Cordes, Carsten; Gollwitzer-Meier-Klinik, D-32545 Bad Oeynhausen, Germany, sy.ca.cordes@gmail.com
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    Dörr, Gesine; Alexianer St. Josefs-Krankenhaus Potsdam, D-14472 Potsdam, Germany, G.Doerr@alexianer.de
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    Eichler, Sarah; Department of Rehabilitation Medicine, Faculty of Health Sciences Brandenburg, University of Potsdam, D-14469 Potsdam, Germany, saraheichler@t-online.de
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    Exner, Anne-Kathrin; Klinikum Lippe GmbH, Standort Detmold, D-32756 Detmold, Germany, Anne-Kathrin.Exner@klinikum-lippe.de
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    Fromm, Bernd; REHA-Klinik Sigmund Weil, D-76669 Bad Schönborn, Germany, b.fromm@sigmund-weil-klinik.de
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    Gielen, Stephan; Klinikum Lippe GmbH, Standort Detmold, D-32756 Detmold, Germany, Stephan.Gielen@klinikum-lippe.de
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    Glatz, Johannes; Reha-Zentrum Seehof der Deutschen Rentenversicherung Bund, D-14513 Teltow, Germany, jglatz@t-online.de
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    Gohlke, Helmut; Private Practice, D-79282 Ballrechten-Dottingen, Germany, h.gohlke@t-online.de
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    Grilli, Maurizio; Library Department, University Medical Centre Mannheim, D-68167 Mannheim, Germany, grillimaurizio@posteo.de
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    Gysan, Detlef; Department für Humanmedizin, Private Universität Witten/Herdecke GmbH, D-58455 Witten, Germany, d.gysan@gesundesherz.de
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    Härtel, Ursula; LMU München, Institut für Medizinische Psychologie, D-80336 München, Germany, ursula.haertel@med.uni-muenchen.de
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    Hahmann, Harry; Private Practice, D-88316 Isny im Allgäu, Germany, harry.hahmann@uni-ulm.de
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    Herrmann-Lingen, Christoph; Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen Medical Center and German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, D-37075 Göttingen, Germany, cherrma@gwdg.de
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    Karger, Gabriele; Private Practice, D-69121 Heidelberg, Germany, kargerga@freenet.de
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    Karoff, Marthin; Private Practice, D-58332 Schwelm, Germany, karoffm@t-online.de
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    Kiwus, Ulrich; Private Practice, D-14169 Berlin, Germany, dr.ulrich.kiwus@t-online.de
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    Knoglinger, Ernst; Kirchberg-Klinik, D-37431 Bad Lauterberg, Germany, knoglinger@kirchbergklinik.de
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    Krusch, Christian-Wolfgang; Private Practice, D-67059 Ludwigshafen, Germany, Christian-Wolfgang.Krusch@arbeitsagentur.de
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    Langheim, Eike; Reha-Zentrum Seehof der Deutschen Rentenversicherung Bund, D-14513 Teltow, Germany, Dr.med.Eike.Langheim@drv-bund.de
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    Mann, Johannes; KfH Nierenzentrum, D-80804 München, Germany, prof.j.mann@gmail.com
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    Max, Regina; Zentrum für Rheumatologie, Drs. Dornacher/Schmitt/Max/Lutz, D-69115 Heidelberg, Germany, DrReginaMax@mail.de
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    Metzendorf, Maria-Inti; Cochrane Metabolic and Endocrine Disorders Group, Institute of General Practice, Medical Faculty of the Heinrich-Heine University, D-40225 Düsseldorf, Germany, maria-inti.metzendorf@med.uni-duesseldorf.de
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    Nebel, Roland; Hermann-Albrecht-Klinik METTNAU, Reha-Einrichtungen der Stadt Radolfzell, D-7385 Radolfzell, Germany, roland.nebel@mettnau.com
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    Niebauer, Josef; Universitätsinstitut für Präventive und Rehabilitative Sportmedizin, Uniklinikum Salzburg, Paracelsus Medizinische Privatuniversität, A-5020 Salzburg, Austria, j.niebauer@salk.at
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    Predel, Hans-Georg; Institute for Cardiology and Sports Medicine, Department of Preventive and Rehabilitative Sport- and Exercise Medicine, German Sportuniversity Cologne, D-50933 Köln, Germany, Predel@dshs-koeln.de
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    Preßler, Axel; Privatpraxis für Kardiologie, Sportmedizin, Prävention, Rehabilitation, D-81675 München, Germany, axel.pressler@kardiologie-mit-herz.de
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    Razum, Oliver; Epidemiologie und International Public Health, Fakultät für Gesundheitswissenschaften, Universität Bielefeld, D-33615 Bielefeld, Germany, oliver.razum@uni-bielefeld.de
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    Reiss, Nils; Schüchtermann-Schiller’sche Kliniken, D-49214 Bad Rothenfelde, Germany, NReiss@schuechtermann-klinik.de
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    Saure, Daniel; Institute of Medical Biometry and Informatics (IMBI), University of Heidelberg, D-69120 Heidelberg, Germany, dsaure55@hotmail.de
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    von Schacky, Clemens; Omegametrix, D-82152 Martinsried, Germany, c.vonschacky@omegametrix.eu
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    Schütt, Morten; Diabetologische Schwerpunktpraxis, D-23552 Lübeck, Germany, morten.schuett@diabetes-luebeck.de
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    Schultz, Konrad; Klinik Bad Reichenhall, Zentrum für Rehabilitation, Pneumologie und Orthopädie, D-83435 Bad Reichenhall, Germany, konradschultz@t-online.de
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    Skoda, Eva-Maria; Clinic for Psychosomatic Medicine and Psychotherapy, LVR University Hospital, University of Duisburg-Essen, D-45147 Essen, Germany, eva-maria.skoda@uni-due.de
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    Steube, Diethard; Private Practice, D-14055 Berlin, Germany, professor.steube@gmx.de
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    Streibelt, Marco; Department for Rehabilitation Research, German Federal Pension Insurance, D-10704 Berlin, Germany, marco.streibelt@drv-bund.de
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    Stüttgen, Martin; Praxis Martin Stüttgen, D-67157 Wachenheim, Germany, Martin@Praxis-Stuettgen.de
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    Stüttgen, Michaela; ZAR Ludwigshafen Klinikum, D-67063 Ludwigshafen am Rhein, Germany, Michaela.stuettgen@zar-ludwigshafen-klinikum.de
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    Teufel, Martin; Clinic for Psychosomatic Medicine and Psychotherapy, LVR University Hospital, University of Duisburg-Essen, D-45147 Essen, Germany, martin.teufel@uni-due.de
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    Tschanz, Hansueli; Berner Reha Zentrum, CH-3625 Heiligenschwendi, Switzerland, h.tschanz@rehabern.ch
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    Völler, Heinz; Department of Rehabilitation Medicine, Faculty of Health Sciences Brandenburg, University of Potsdam, D-14469 Potsdam, Germany, Heinz.Voeller@klinikamsee.com Klinik am See, D-15562 Rüdersdorf, Germany, Heinz.Voeller@klinikamsee.com
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    Vogel, Heiner; Abteilung für Medizinische Psychologie und Psychotherapie, Medizinische Soziologie und Rehabilitationswissenschaften, Universität Würzburg, D-97070 Würzburg, Germany, h.vogel@uni-wuerzburg.de
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    Westphal, Ronja; Herzzentrum Segeberger Kliniken, D-23795 Bad Segeberg, Germany, ronja.westphal@segebergerkliniken.de
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    Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma
    (2015-06-15)
    Freudlsperger, Christian
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    Horn, Dominik
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    Weißfuß, Sebastian
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    Weichert, Wilko
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    Weber, Klaus-Josef
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    Saure, Daniel
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    Sharma, Sarika
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    Dyckhoff, Gerhard
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    Grabe, Niels  
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    Plinkert, Peter
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    Hoffmann, Jürgen
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    Freier, Kolja
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    Hess, Jochen
    Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by high resistance to radiotherapy, which critically depends on both altered signaling pathways within tumor cells and their dynamic interaction with the tumor microenvironment. This study evaluated the prognostic value of the phosphorylation status of AKT on Ser473 and Thr308 for the clinical outcome of patients with advanced HNSCC on radiotherapy. Furthermore, we investigated the impact of AKT(Ser473) phosphorylation [p-AKT(Ser473)] in the context of radioresistance using ex vivo tissue cultures that resemble the complex tissue architecture and paracrine interaction with the tumor microenvironment. In a cohort of 120 patients with advanced HNSCC, who were treated with primary or adjuvant radiotherapy, a significant association was found between relative p-AKT(Ser473) levels and overall survival (p = 0.006) as well as progression-free survival (p = 0.021), while no significant correlation was revealed for relative p-AKT(Thr308) levels. In ex vivo tissue cultures p-AKT(Ser473) levels were increased upon irradiation and treatment with the PI3K inhibitor LY294002 inhibited both basal and irradiation induced AKT(Ser473) phosphorylation. Strikingly, pretreatment with LY294002 sensitized tissue cultures derived from primary and recurrent tumors to radiotherapy as determined by impaired tumor cell proliferation and enhanced DNA damage. In conclusion, phosphorylation status of AKT(Ser473) in tumor specimens serves as a novel biomarker to identify patients with advanced HNSCC at high risk for treatment failure following radiotherapy, and our data from ex vivo tissue cultures support the assumption that pharmacological inhibition of AKT(Ser473) phosphorylation might circumvent radioresistance to improve efficiency and reduce toxicity of current treatment modalities.