Browsing by Author "Pattyn, Filip"

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    Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    (2008-10-13)
    Westermann, Frank
    ;
    Muth, Daniel
    ;
    Benner, Axel
    ;
    Bauer, Tobias
    ;
    Henrich, Kai-Oliver
    ;
    Oberthuer, André
    ;
    Brors, Benedikt
    ;
    Beißbarth, Tim  
    ;
    Vandesompele, Jo
    ;
    Pattyn, Filip
    ;
    Hero, Barbara
    ;
    König, Rainer
    ;
    Fischer, Matthias
    ;
    Schwab, Manfred
    Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and identifies a highly aggressive subtype. In MYCN single-copy neuroblastomas, elevated MYCN mRNA and protein levels are paradoxically associated with a more favorable clinical phenotype, including disseminated tumors that subsequently regress spontaneously (stage 4s-non-amplified). In this study, we asked whether distinct transcriptional MYCN or c-MYC activities are associated with specific neuroblastoma phenotypes.