Browsing by Author "Li, Gang"

We present a concept for a small mission to the Sun-Earth Lagrangian L5 point for innovative solar, heliospheric and space weather science. The proposed INvestigation of Solar-Terrestrial Activity aNd Transients (INSTANT) mission is designed to identify how solar coronal magnetic fields drive eruptions, mass transport and particle acceleration that impact the Earth and the heliosphere. INSTANT is the first mission designed to (1) obtain measurements of coronal magnetic fields from space and (2) determine coronal mass ejection (CME) kinematics with unparalleled accuracy. Thanks to innovative instrumentation at a vantage point that provides the most suitable perspective view of the Sun-Earth system, INSTANT would uniquely track the whole chain of fundamental processes driving space weather at Earth. We present the science requirements, payload and mission profile that fulfill ambitious science objectives within small mission programmatic boundary conditions. (C) 2016 Elsevier Ltd. All rights reserved.

Two new compounds containing the decalin moiety, eupenicinicols A and B (1 and 2), two new sirenin derivatives, eupenicisirenins A and B (3 and 4), and four known compounds, (2S)-butylitaconic acid (5), (2S)-hexylitaconic acid (6), xanthomegnin (7), and viridicatumtoxin (8), were isolated from an endophytic fungus, Eupenicillium sp. LG41, harbored in the roots of the Chinese medicinal plant Xanthium sibiricum. Their structures were confirmed through combined spectroscopic analysis (NMR and HRMS(n)), and their absolute configurations were deduced by ECD calculations or optical rotation data. Since the endophytic fungus was isolated from the roots, the antibacterial efficacies of the compounds 1-6 were investigated against Bacillus subtilis and Acinetobacter sp. BD4, which typically inhabit soil, as well as the clinically important Staphylococcus aureus and Escherichia coli. (2S)-Butylitaconic acid (5) and (2S)-hexylitaconic acid (6) exhibited pronounced efficacy against Acinetobacter sp., corroborating the notion that root-endophytes provide chemical defense to the host plants. Compound 2 was highly active against the clinically relevant S. aureus. By comparing 1 with 2, it was revealed that altering the substitution at C-11 could drastically increase the antibacterial efficacy of 1. Our study reveals plausible ecological roles of the endophyte and its potential pharmaceutical use as a source of antibacterial compounds.

An endophytic fungus, Eupenicillium sp. LG41, isolated from the Chinese medicinal plant Xanthium sibiricum, was subjected to epigenetic modulation using an NAD(+)-dependent histone deacetylase (HDAC) inhibitor, nicotinamide. Epigenetic stimulation of the endophyte led to enhanced production of two hew decalin-containing compounds, eupenicinicols C and D (3 and 4), along with two biosynthetically related known compounds, eujavanicol A (1) and eupeniciincol A (2). The structures and stereochemistry of the new compounds were elucidated by extensive spectroscopic analysis using LC-HRMS, NMR, optical rotation, and ECU calculations, as well as single-crystal X-ray diffraction. Compounds 3 and 4 exist in chemical equilibrium with two and three, cis/trans isomers, respectively, as revealed by LC-MS analysis. Compound 4 was active against Staphylococcus aureus with an MIC of 0.1 mu g/mL and demonstrated marked cytotoxicity against the human acute monocytic leukemia cell line (THP-1). We have shown that the HDAC inhibitor, nicotinamide, enhanced the production of compounds 3 and 4 by endophytic Eupenicillium sp. LG41, facilitating their isolation, structure elucidation, and evaluation of their biological activities.

Context. The Transiting Exoplanet Survey Satellite (TESS) performs high-precision photometry over almost the whole sky primarily in search of exoplanet transits. It also provides exquisite data to study stellar variability, in particular for pulsating hot B subdwarf (sdB) stars. Aims. We present a detailed analysis of a new hybrid ( p - and g -mode) sdB pulsator, TIC 441725813 (TYC 4427-1021-1), discovered and monitored by TESS for 670 days. Methods. The TESS light curves available for this star were analysed using prewhitening techniques to extract mode frequencies accurately. The pulsation spectrum was then interpreted through methods that include asymptotic period spacing relationships and the identification of rotational multiplets. We also exploited a high signal-to-noise ratio (S/N), low-resolution spectrum of TIC 441725813 using grids of non-local thermodynamic equilibrium (NLTE) model atmospheres to derive its atmospheric parameters. Results. The light curve analysis reveals that frequencies are mostly found in the g -mode region, but several p -modes are also detected, indicating that TIC 441725813 is a hybrid sdB pulsator. We identify 25 frequencies that can be associated with ℓ  = 1 g -modes, 15 frequencies corresponding to ℓ  = 2 g -modes, and six frequencies characteristic of p -modes. Interestingly, several frequency multiplets interpreted as rotational splittings of deep-probing g -modes indicate a slow rotation period of at least 85.3 ± 3.6 day, while splittings of mostly envelope-probing p -modes suggest a significantly shorter rotation period of 17.9 ± 0.7 day, which implies the core (mainly the helium mantle with possibly the deeper partially mixed helium-burning core that it surrounds) rotates at least 4.7 times slower than the envelope. The radial velocity curves indicate that TIC 441725813 is in a close binary system with a low-luminosity companion, possibly a white dwarf. While elusive in the available TESS photometry, a low-frequency signal that would correspond to a period of ∼6.7 h is found, albeit at a low S/N. Furthermore, we estimate the inclination angle to be ∼60° by two independent means. Conclusions. TIC 441725813 is a particularly interesting sdB star whose envelope rotates faster than the core. We hypothesise that this might be caused by the effects of a tidal interaction with a companion, although in the present case, the presence of such a companion will have to be further investigated. This analysis paves the way towards a more detailed seismic probing of TIC 441725813 using optimisation techniques, which will be presented in a second paper.