Browsing by Author "Levendis, Demetrius C."

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Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate
(Royal Soc Chemistry, 2014)
Fabbiani, Francesca P. A.
;
Buth, Gernot
;
Levendis, Demetrius C.
;
Cruz-Cabez, Aurora J.
The monohydrate form of the neurotransmitter gamma-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
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Searching for novel crystal forms by in situ high-pressure crystallisation: the example of gabapentin heptahydrate
(Royal Soc Chemistry, 2010)
Fabbiani, Francesca P. A.
;
Levendis, Demetrius C.
;
Buth, Gernot
;
Kuhs, Werner F.
;
Shankland, Norman
;
Sowa, Heidrun
High-pressure crystallisation of an aqueous solution of the GABA analogue gabapentin at 0.8 GPa resulted in the formation of a previously unknown heptahydrate form, whose structure has been determined by in situ single-crystal X-ray diffraction. The structure and water framework of this unusually highly hydrated small molecule are described in detail.