Browsing by Author "Cremer, C."

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    Genome function and nuclear architecture: From gene expression to nanoscience
    (Cold Spring Harbor Lab Press, Publications Dept, 2003)
    O’Brien, T. P.
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    Bult, C. J.
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    Cremer, C.
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    Grunze, M.
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    Knowles, B. B.
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    Langowski, J.
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    McNally, J.
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    Pederson, T.
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    Politz, J. C.
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    Pombo, A.
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    Schmahl, Günter  
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    Spear, Stephen F.
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    van Driel, R.
    Biophysical, chemical, and nanoscience approaches to the study Of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.
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    Two‐photon excitation 4Pi confocal microscope: Enhanced axial resolution microscope for biological research
    (1995)
    Hänninen, P. E.
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    Hell, S. W.  
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    Salo, J.
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    Soini, E.
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    Cremer, C.
    The applicability of two photon excitation 4Pi confocal fluorescence microscopy to biological imaging is demonstrated. We show that 4Pi confocal microscopy in combination with a simple deconvolution algorithm allows axial localization and quantification with 0.14 μm resolution in a biological sample. The 4Pi‐confocal microscope extends the applicability of far field fluorescence microscopy to high resolution three‐dimensional imaging and quantification of subcellular structures.