Browsing by Author "Bauer, Michaela"

C–H arylations were accomplished with a user-friendly heterogeneous palladium catalyst in the biomass-derived c-valerolactone (GVL) as an environmentally-benign reaction medium. The userfriendly protocol was characterized by ample substrate scope and high functional group tolerance in the C–H arylation of 1,2,3- triazoles, and the palladium catalyst could be recycled and reused in the C–H activation process.

The bioorthogonal late-stage diversification of functionalized oligopeptides was accomplished through a metal-free, site-selective C-H arylation of engineered indole derivatives under mild reaction conditions.

The step-economical late-stage diversification of tryptophan-containing peptides was accomplished through chemo- and site-selective palladium-catalyzed CH arylation under exceedingly mild reaction conditions. Thus, the CH functionalization occurred efficiently at 23 degrees C with a catalyst loading as low as 0.5mol%, and/or in H2O.