Browsing by Author "Aggensteiner, Pascal-M."

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    A stable and replicable neural signature of lifespan adversity in the adult brain
    (2023)
    Holz, Nathalie E.
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    Zabihi, Mariam
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    Kia, Seyed Mostafa
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    Monninger, Maximillian
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    Aggensteiner, Pascal-M.
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    Siehl, Sebastian
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    Floris, Dorothea L.
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    Bokde, Arun L. W.
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    Desrivières, Sylvane
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    Flor, Herta
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    Marquand, Andre F.
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    IMAGEN Consortium
    Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years ( n  = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years ( n  = 114) and in an independent sample at 22 years ( n  = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.
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    EEG Data Quality: Determinants and Impact in a Multicenter Study of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
    (MDPI, 2021)
    Kaiser, Anna
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    Aggensteiner, Pascal-M.
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    Holtmann, Martin  
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    Fallgatter, Andreas
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    Romanos, Marcel
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    Abenova, Karina
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    Alm, Barbara
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    Becker, Katja
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    Döpfner, Manfred
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    Ethofer, Thomas
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    Freitag, Christine
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    Geissler, Julia
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    Hebebrand, Johannes
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    Huss, Michael
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    Jans, Thomas
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    Jendreizik, Lea
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    Ketter, Johanna
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    Legenbauer, Tanja
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    Philipsen, Alexandra
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    Poustka, Luise  
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    Renner, Tobias
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    Retz, Wolfgang
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    Rösler, Michael
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    Thome, Johannes
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    Uebel-von Sandersleben, Henrik  
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    von Wirth, Elena
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    Zinnow, Toivo
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    Hohmann, Sarah
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    Millenet, Sabina
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    Holz, Nathalie
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    Banaschewski, Tobias  
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    Brandeis, Daniel
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    Kaiser, Anna; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, anna.kaiser@zi-mannheim.de
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    Aggensteiner, Pascal-M.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Pascal.Aggensteiner@zi-mannheim.de
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    Holtmann, Martin; LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany, martin.holtmann@lwl.org
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    Fallgatter, Andreas; Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany, Andreas.Fallgatter@med.uni-tuebingen.de
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    Romanos, Marcel; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Romanos_M@ukw.de
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    Abenova, Karina; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Karina.Abenova@zi-mannheim.de
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    Alm, Barbara; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Barbara.Alm@zi-mannheim.de
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    Becker, Katja; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany, katja.becker@med.uni-marburg.de Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, 35032 Marburg, Germany, katja.becker@med.uni-marburg.de
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    Döpfner, Manfred; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, manfred.doepfner@uk-koeln.de
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    Ethofer, Thomas; Tübingen University Hospital for Psychiatry and Psychotherapy, 72076 Tübingen, Germany, Thomas.Ethofer@med.uni-tuebingen.de
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    Freitag, Christine; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, Goethe University, 60323 Frankfurt am Main, Germany, C.Freitag@em.uni-frankfurt.de
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    Geissler, Julia; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Geissler_J@ukw.de
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    Hebebrand, Johannes; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany, johannes.hebebrand@lvr.de
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    Huss, Michael; Department of Child and Adolescent Psychiatry, University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany, m.huss@rfk.landeskrankenhaus.de
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    Jans, Thomas; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, 97080 Würzburg, Germany, Jans_T@ukw.de
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    Jendreizik, Lea; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, lea.jendreizik@uk-koeln.de
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    Ketter, Johanna; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty Philipps-University Marburg and University Hospital Marburg, 35039 Marburg, Germany, ketterj@med.uni-marburg.de
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    Legenbauer, Tanja; LWL-University Hospital for Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Ruhr University Bochum, 59071 Hamm, Germany, tanja.legenbauer@lwl.org
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    Philipsen, Alexandra; Department of Psychiatry and Psychotherapy, University of Bonn, 53127 Bonn, Germany, Alexandra.Philipsen@ukbonn.de
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    Poustka, Luise; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany, luise.poustka@med.uni-goettingen.de
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    Renner, Tobias; Department of Child and Adolescence Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany, tobias.renner@med.uni-tuebingen.de
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    Retz, Wolfgang; Department of Psychiatry and Psychotherapy, University Medical Center Mainz, 55131 Mainz, Germany, wolfgang.retz@unimedizin-mainz.de Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, wolfgang.retz@unimedizin-mainz.de
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    Rösler, Michael; Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, Michael.Roesler@uks.eu
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    Thome, Johannes; Department of Psychiatry and Psychotherapy, University Medical Center Rostock, 18055 Rostock, Germany, johannes.thome@med.uni-rostock.de
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    Uebel-von Sandersleben, Henrik; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, 37075 Göttingen, Germany, huebel@gwdg.de
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    von Wirth, Elena; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany, elena.von-wirth@uk-koeln.de
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    Zinnow, Toivo; Institute for Forensic Psychology and Psychiatry, Saarland University, 66424 Homburg, Germany, Toivo.Zinnow@uks.eu
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    Hohmann, Sarah; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Sarah.Hohmann@zi-mannheim.de
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    Millenet, Sabina; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Sabina.Millenet@zi-mannheim.de
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    Holz, Nathalie; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, Nathalie.Holz@zi-mannheim.de
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    Banaschewski, Tobias; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, 68159 Mannheim, Germany, tobias.banaschewski@zi-mannheim.de
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    ESCAlife-Consortium
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